The Commission of the European Union (EU) has amended its regulations on the registration, evaluation, authorization and restriction of chemicals (REACH) to adopt a new protocol for mandated toxicity studies.
Published in the Official Journal of the European Union in February 2015, Commission Regulation (EU) 2015/282 amends key Annexes of the original REACH Regulation (EC No 1907/2006) to permit the use of so-called extended one-generation reproductive toxicity studies (EOGRTS) in assessing the reproductive toxicity of chemical substances. EOGRTS are reported to have a number of advantages over two-generational reproductive toxicity studies, including a reduction in the number of test animals used and an improvement in the sensitivity and level of information obtained from testing.
